ACE, angiotensin I converting enzyme, 1636

N. diseases: 1082; N. variants: 82
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0009402
Disease:
Colorectal Carcinoma
0.010 GeneticVariation BEFREE Our findings suggest that the angiotensin-converting enzyme I/D and angiotensinogen M235T polymorphisms are unlikely to correlate with colorectal cancer. 31642377 2020
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C4722085
Disease:
Malignant neoplasm of colon and/or rectum
0.010 GeneticVariation BEFREE Our findings suggest that the angiotensin-converting enzyme I/D and angiotensinogen M235T polymorphisms are unlikely to correlate with colorectal cancer. 31642377 2020
dbSNP: rs4343
rs4343
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0742343
Disease:
Acute Chest Syndrome
0.010 GeneticVariation BEFREE This study aims to investigate the impact of ACE (rs4343) and AT1R (rs 5182) genetic polymorphisms on the outcome of acute coronary syndrome (ACS) in patients on captopril. 31195108 2020
dbSNP: rs4343
rs4343
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0948089
Disease:
Acute Coronary Syndrome
0.010 GeneticVariation BEFREE This study aims to investigate the impact of ACE (rs4343) and AT1R (rs 5182) genetic polymorphisms on the outcome of acute coronary syndrome (ACS) in patients on captopril. 31195108 2020
dbSNP: rs149155892
rs149155892
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0005890
Disease:
Body Height
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs4291
rs4291
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0871470
Disease:
Systolic Pressure
T 0.700 GeneticVariation GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0038454
Disease:
Cerebrovascular accident
0.030 GeneticVariation BEFREE The M235T and T174M polymorphisms represented an increased risk for stroke in young Mexican individuals. 30521887 2019
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0948008
Disease:
Ischemic stroke
0.020 GeneticVariation BEFREE There were independent factors for ischemic stroke: M235T and T174M polymorphisms, smoking, hypertension, and familial history of atherothrombotic disease. 30521887 2019
dbSNP: rs1205538057
rs1205538057
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE G-containing genotypes (AG + GG) and G allele of AT2R in intron 1 (A1675G) were more frequent in SLE patients compared to controls ( p = 0.01, OR = 2.3, 95% CI = 1.2-4.5; p = 0.02, OR = 2.1, 95% CI = 1.2-3.7, respectively). 30621494 2019
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0410158
Disease:
Muscle damage
0.010 GeneticVariation BEFREE Muscle damage was also determined fifteen days after race and angiotensinogen (<i>AGT</i>) Met235Thr, angiotensin-converting enzyme (<i>ACE</i>) I/D, and Bradykinin B2 receptor (<i>BDKRB2</i>) -9/+9 polymorphisms were determined. 31708962 2019
dbSNP: rs1339023151
rs1339023151
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE The objective of this research is to study AT2R gene polymorphisms in exon 3 (C1593A) and intron 1 (A1675G) in Egyptian children with SLE and its correlation with disease manifestations and serum angiotensin-converting enzyme (ACE) level. 30621494 2019
dbSNP: rs1799752
rs1799752
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0020538
Disease:
Hypertensive disease
0.010 GeneticVariation BEFREE We did not observe associations between hypertension and rs1799752 (<i>P</i>=0.422), rs699 (<i>P</i>=0.36), rs5186 (<i>P</i>=0.49), and rs1799998 (<i>P</i>=0.71). 31511791 2019
dbSNP: rs4331
rs4331
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C4021107
Disease:
Non-obstructive azoospermia
0.010 GeneticVariation BEFREE CONCLUSIONS No significant association was found between ACE SNPs rs4316, rs4331, rs4343, or rs4362 and NOA in the Chinese Han population of Northeast China. 31198195 2019
dbSNP: rs4343
rs4343
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C4021107
Disease:
Non-obstructive azoospermia
0.010 GeneticVariation BEFREE CONCLUSIONS No significant association was found between ACE SNPs rs4316, rs4331, rs4343, or rs4362 and NOA in the Chinese Han population of Northeast China. 31198195 2019
dbSNP: rs4362
rs4362
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C4021107
Disease:
Non-obstructive azoospermia
0.010 GeneticVariation BEFREE CONCLUSIONS No significant association was found between ACE SNPs rs4316, rs4331, rs4343, or rs4362 and NOA in the Chinese Han population of Northeast China. 31198195 2019
dbSNP: rs754618480
rs754618480
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset
0.010 GeneticVariation BEFREE APOE, MTHFR A1298C and BDNF C270T polymorphisms may be associated with LOAD and BDNF and MTHFR alleles may play a role in the age at onset of the LOAD. 31102717 2019
dbSNP: rs4311
rs4311
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0002395
Disease:
Alzheimer's Disease
0.700 GeneticVariation GWASCAT GWAS on family history of Alzheimer's disease. 29777097 2018
dbSNP: rs4344
rs4344
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C2985280
Disease:
Blood Protein Measurement
A 0.700 GeneticVariation GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
dbSNP: rs1799752
rs1799752
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C1956346
Disease:
Coronary Artery Disease
0.030 GeneticVariation BEFREE This study aimed to verify the possible influence of apolipoprotein B (ApoB: rs1042031 and rs693) and angiotensin-converting enzyme (ACE-ID: rs1799752) genotypes on the lipid profile and functional aerobic capacity, respectively, after an aerobic interval training (AIT) program in patients with CAD and/or cardiovascular risk factors. 29846435 2018
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0155626
Disease:
Acute myocardial infarction
0.010 GeneticVariation BEFREE There was a significant difference in the insertion deletion genotype distribution between two groups (P = 0.03) and a higher percentage of the T allele M235T polymorphism in the group of STEAMI patients (P = 0.02). 29474203 2018
dbSNP: rs1799752
rs1799752
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0026769
Disease:
Multiple Sclerosis
0.010 GeneticVariation BEFREE We found significant overrepresentation of the I allele of the rs1799752 in MS</span> patients compared with healthy subjects (Adjusted P value = 0.03, OR (95% CI) = 1.28 (1.05-1.57). 30218954 2018
dbSNP: rs767425642
rs767425642
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0497327
Disease:
Dementia
0.010 GeneticVariation BEFREE The association between dementia risk and all the studied polymorphisms except of PON1-Q192R was found to be significant. 28657841 2018
dbSNP: rs767425642
rs767425642
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0011265
Disease:
Presenile dementia
0.010 GeneticVariation BEFREE The association between dementia risk and all the studied polymorphisms except of PON1-Q192R was found to be significant. 28657841 2018
dbSNP: rs4295
rs4295
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0428883
Disease:
Diastolic blood pressure
C 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs4295
rs4295
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0871470
Disease:
Systolic Pressure
C 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017